Napoli need a victory to stay top of the Serie A table with Romelu Lukaku, Scott McTominay and Khvicha Kvaratskhelia, but Lazio have similar ambitions with Taty Castellanos and Matteo Guendouzi.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
With Atalanta registering a ninth consecutive victory, La Dea are temporarily in top spot and only a win here would allow Antonio Conte to recapture the leadership.
Curiously, Napoli already faced Lazio in the Coppa Italia Round of 16 on Thursday and were beaten 3-1 at the Stadio Olimpico by a Tijjani Noslin hat-trick.
However, that is a totally different starting XI to tonight, where only Pasquale Mazzocchi is out injured.
Lukaku, Kvaratskhelia and Matteo Politano were all rested midweek and return here with McTominay and Stanislav Lobotka in midfield.
Lazio rotated too in the Coppa Italia, albeit not quite in such extreme fashion, and saw their run of five consecutive Serie A victories ended by a 3-1 loss at Parma.
Nicolò Rovella is suspended with Matias Vecino injured, but Nuno Tavares and Luca Pellegrini are back in the squad.
Guendouzi pulls the midfield strings behind Gustav Isaksen, Boulaye Dia, Mattia Zaccagni and Castellanos.
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno, Olivera; Anguissa, Lobotka, McTominay; Politano, Lukaku, Kvaratskhelia
Lazio: Provedel; Marusic, Gila, Romagnoli, Nuno Tavares; Guendouzi, Dele-Bashiru; Isaksen, Dia, Zaccagni; Castellanos
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