Ange Postecoglou has confirmed Ben Davies has suffered had a setback in his recovery from a hamstring injury, as the defensive crisis at Tottenham deepens.
Davies returned to training last week and Postecoglou said he hoped the left-sided defender could return against Wolves on December 29.
But Postecoglou says Davies is facing another “couple of weeks” after breaking down in training.
Spurs are also waiting to learn the full extent of the ankle injury suffered by Radu Dragusin in the 1-0 defeat at Nottingham Forest on Boxing Day.
Postecoglou is already without Micky van de Ven and Cristian Romero and if Dragusin is not fit to face Wolves then he will need to find someone to partner Archie Gray in central defence.
Speaking on Friday, Postecoglou said: “Davies is ruled out, unfortunately had a setback in training so he’s out for a couple of weeks.
“It’s the same injury. He tried to come back in training but it didn’t work out.”
On Dragusin, Postecoglou said: “A bit early to tell. Obviously he tweaked his ankle last night, he felt like he couldn’t continue so we’ll have to wait and see.”
Asked whether Bissouma could start at centre-back against Wolves, Postecoglou said: “Yves has never played there so I’m not sure why I would put him there. We’ll see.”
Youngster Alfie Dorrington is an option for Postecoglou. The 19-year-old made his Spurs debut as a substitute in the 5-0 win at Southampton this month.